| henryjame012's Forum Info |
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| Additional Info About henryjame012 |
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| Bio: |
Abiraterone 250 mg (Zytiga) is an inhibitor of androgen biosynthesis. In particular, Abiraterone 250 mg (Zytiga) selectively inhibits the activity of the 17α-hydroxylase / C17,20-lyase (CYP17) enzyme. This enzyme is essential for the biosynthesis of androgens in the testes, adrenal glands, and prostate tumor cells. CYP17 catalyzes the conversion of pregnenolone and progesterone by 17α-hydroxylation and cleavage of the C17,20 bond to testosterone precursors: dehydroepiandrosterone and androstenedione, respectively. Inhibition of CYP17 activity is also accompanied by an increase in the synthesis of mineralocorticoids in the adrenal glands. Antiandrogen therapy, such as the use of luliberin agonists or orchiectomy, attenuates androgen synthesis in the testes, but does not affect androgen synthesis in the adrenal glands and tumors. The use of Abiraterone Cost in Jamaica 250 mg (Zytiga) in conjunction with luliberin agonists (or orchidectomy) reduces the serum testosterone concentration to a level below the detection threshold. The concentration of prostate-specific antigen (PSA) serves as a biomarker in patients with prostate cancer. When taken orally, Abiraterone 250 mg (Zytiga) acetate is converted into an active metabolite, Abiraterone 250 mg (Zytiga), which has antiandrogenic activity. Joint intake with food increases the absorption of the drug and, therefore, can increase and greatly change the effect of the drug, therefore, Abiraterone 250 mg (Zytiga) should be taken on an empty stomach. The drug binds well to proteins (> 99%) and is metabolized in the liver with the participation of CYP3A4 and SULT2A1 to inactive metabolites. Abiraterone 250 mg (Zytiga) is excreted in feces (~ 88%) and urine (~ 5%). The final half-life is 12 ± 5 hours. |
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